Unravelling 2-oxoglutarate turnover and substrate oxidation dynamics in 5-methylcytosine-oxidising TET enzymes
Abstract Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenases use 2OG and O2 cofactors to catalyse substrate oxidation and yield oxidised product, succinate, and CO2. Simultaneous detection of substrate and cofactors is difficult, contributing to a poor understanding of the dynamics between subst...
| Hauptverfasser: | , , |
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| Format: | Artikel |
| Sprache: | English |
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Nature Portfolio
2024-12-01
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| Schriftenreihe: | Communications Chemistry |
| Online Zugang: | https://doi.org/10.1038/s42004-024-01382-1 |