Single-cell RNA-sequencing analysis reveals the molecular mechanism of subchondral bone cell heterogeneity in the development of osteoarthritis

The cellular composition and underlying spatiotemporal transformation processes of subchondral bone in osteoarthritis (OA) remain unknown. Herein, various cell subsets from tibial plateau of patients with OA are identified, and the mechanism of subchondral microstructure alteration is elaborated usi...

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Bibliographic Details
Main Authors: Hao Zhang, Yan Hu, Ke Xu, Xiao Chen, Han Liu, Jin Cui, JiaWei Guo, Sicheng Wang, Qirong Zhou, Liehu Cao, Jiacan Su
Format: Article
Language:English
Published: BMJ Publishing Group 2022-11-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/8/2/e002314.full