The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors

The Oncogenic Roles of DICER1 RNase IIIb Domain Mutations in Ovarian Sertoli-Leydig Cell Tumors

DICER1, an endoribonuclease required for microRNA (miRNA) biogenesis, is essential for embryogenesis and the development of many organs including ovaries. We have recently identified somatic hotspot mutations in RNase IIIb domain of DICER1 in half of ovarian Sertoli-Leydig cell tumors, a rare class...

Full description

Bibliographic Details
Main Authors: Yemin Wang, Jiamin Chen, Winnie Yang, Fan Mo, Janine Senz, Damian Yap, Michael S. Anglesio, Blake Gilks, Gregg B. Morin, David G. Huntsman
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558615000998

Internet

http://www.sciencedirect.com/science/article/pii/S1476558615000998

Similar Items