PLAP -CAR Tcells mediate high specific cytotoxicity against colon cancer cells

PLAP -CAR Tcells mediate high specific cytotoxicity against colon cancer cells

Placental alkaline phosphatase, PLAP encoded by ALPP gene in humans is mainly expressed in placenta and testis, and not expressed in any other normal tissues. PLAP is overexpressed in colorectal cancers which makes it an attractive target for CAR (chimeric antigen receptor)-T cell therapy. PLAP mRNA...

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Bibliographic Details
Main Authors: Xin Li, Robert Berahovich, Hua Zhou, Xianghong Liu, Feng Li, Shirley Xu, Yuehua Wei, Djamila Ouaret, Walter Bodmer, Lijun Wu, Vita Golubovskaya
Format: Article
Language:English
Published: IMR Press 2020-06-01
Series:Frontiers in Bioscience-Landmark
Subjects:
chimeric antigen receptor
immunotherapy
cancer
plap
checkpoint inhibitor
Online Access:https://www.imrpress.com/journal/FBL/25/9/10.2741/4877

Internet

https://www.imrpress.com/journal/FBL/25/9/10.2741/4877

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