Cyclic mechanical loading of photopolymerized methacrylated hydrogels for probing interdependent effects of strain, stiffness, and substrate composition in pulmonary fibrogenesis
Abstract Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix (ECM), stiffening of the lung tissue, and impaired gas exchange. Our current understanding of fibrogenesis generally focuses on the individual roles of mechanical and biochemical stimuli in driving disease p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-90753-2 |