Schistosoma mansoni infection induces plasmablast and plasma cell death in the bone marrow and accelerates the decline of host vaccine responses.

Schistosomiasis is a potentially lethal parasitic disease that profoundly impacts systemic immune function in chronically infected hosts through mechanisms that remain unknown. Given the immunoregulatory dysregulation experienced in infected individuals, this study examined the impact of chronic sch...

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Bibliographic Details
Main Authors: Fungai Musaigwa, Severin Donald Kamdem, Thabo Mpotje, Paballo Mosala, Nada Abdel Aziz, De'Broski R Herbert, Frank Brombacher, Justin Komguep Nono
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010327