Mass-spectrometry analysis of modifications at DNA termini induced by DNA polymerases

Abstract Non-natural nucleotide substrates are widely used in the enzymatic synthesis of modified DNA. The terminal activity of polymerases in the presence of modified nucleotides is an important, but poorly characterized, aspect of enzymatic DNA synthesis. Here, we studied different types of polyme...

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Bibliographic Details
Main Authors: Igor P. Smirnov, Natalia A. Kolganova, Vadim A. Vasiliskov, Alexander V. Chudinov, Edward N. Timofeev
Format: Article
Language:English
Published: Nature Portfolio 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-06136-9