Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya

Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya

IntroductionGlobally, many young women face the overlapping burden of HIV infection and unintended pregnancy. Protection against both may benefit from safe and effective multipurpose prevention technologies.MethodsHealthy women ages 18–34 years, not pregnant, seronegative for HIV and hepatitis B sur...

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Main Authors: Nelly R. Mugo, Victor Mudhune, Renee Heffron, Katherine K. Thomas, Eleanor McLellan-Lemal, Betty Njoroge, Sue Peacock, Siobhán M. O’Connor, Beatrice Nyagol, Eunice Ouma, Renee Ridzon, Jeffrey Wiener, Nina Isoherranen, David W. Erikson, Louise A. Ouattara, Nazita Yousefieh, Terry A. Jacot, Richard E. Haaland, Susan A. Morrison, Harald S. Haugen, Andrea R. Thurman, Shannon A. Allen, Jared M. Baeten, Taraz Samandari, Gustavo F. Doncel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Reproductive Health
Subjects:
intravaginal ring
multipurpose technology
tenofovir
levonorgestrel
HIV
HSV-2
Online Access:https://www.frontiersin.org/articles/10.3389/frph.2023.1118030/full

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https://www.frontiersin.org/articles/10.3389/frph.2023.1118030/full

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