O-Mannosylation of Proteins Enables <italic toggle="yes">Histoplasma</italic> Yeast Survival at Mammalian Body Temperatures

O-Mannosylation of Proteins Enables <italic toggle="yes">Histoplasma</italic> Yeast Survival at Mammalian Body Temperatures

ABSTRACT The ability to grow at mammalian body temperatures is critical for pathogen infection of humans. For the thermally dimorphic fungal pathogen Histoplasma capsulatum, elevated temperature is required for differentiation of mycelia or conidia into yeast cells, a step critical for invasion and...

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Bibliographic Details
Main Authors: Andrew L. Garfoot, Kristie D. Goughenour, Marcel Wüthrich, Murugesan V. S. Rajaram, Larry S. Schlesinger, Bruce S. Klein, Chad A. Rappleye
Format: Article
Language:English
Published: American Society for Microbiology 2018-03-01
Series:mBio
Subjects:
Histoplasma
glycosylation
mannose
phagocyte
thermotolerance
Online Access:https://journals.asm.org/doi/10.1128/mBio.02121-17

Internet

https://journals.asm.org/doi/10.1128/mBio.02121-17

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