Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis

Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis

ABSTRACT Cryptococcal meningitis causes an estimated 112,000 global deaths per annum. Genomic and phenotypic features of the infecting strain of Cryptococcus spp. have been associated with outcomes from cryptococcal meningitis. Additionally, population-level pharmacokinetic variability is well docum...

Full description

Bibliographic Details
Main Authors: Katharine E. Stott, Jason T. Mohabir, Katharine Bowers, Jennifer L. Tenor, Dena L. Toffaletti, Jennifer Unsworth, Ana Jimenez-Valverde, Ajisa Ahmadu, Melanie Moyo, Ebbie Gondwe, Wezi Chimang’anga, Madalitso Chasweka, David S. Lawrence, Joseph N. Jarvis, Tom Harrison, William Hope, David G. Lalloo, Henry C. Mwandumba, John R. Perfect, Christina A. Cuomo
Format: Article
Language:English
Published: American Society for Microbiology 2024-10-01
Series:mBio
Subjects:
Cryptococcus
pharmacokinetics
pharmacodynamics
cryptococcal meningitis
genomics
Online Access:https://journals.asm.org/doi/10.1128/mbio.01592-24

Internet

https://journals.asm.org/doi/10.1128/mbio.01592-24

Similar Items