β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis

β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis

PurposeRecent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression. However, the importance of β2-AR has not yet been investigated in k...

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Bibliographic Details
Main Authors: Gundula Rösch, Dominique Muschter, Shahed Taheri, Karima El Bagdadi, Christoph Dorn, Andrea Meurer, Frank Zaucke, Arndt F. Schilling, Susanne Grässel, Rainer H. Straub, Zsuzsa Jenei-Lanzl
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
β2-adrenoceptor
subchondral bone
cartilage
synovium
leptin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.801505/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.801505/full

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