Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy

Abstract Immune checkpoint blockade (ICB) therapy has demonstrated good efficacy in many cancer types. In cancers such as non-resectable advanced or metastatic triple-negative breast cancer (TNBC), it has recently been approved as a promising treatment. However, clinical data shows overall response...

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Bibliographic Details
Main Authors: Ethan Shelkey, David Oommen, Elizabeth R. Stirling, David R. Soto-Pantoja, Katherine L. Cook, Yong Lu, Konstantinos I. Votanopoulos, Shay Soker
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-13930-7