Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

Abstract Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that mainly controls histone H2A Lys119 mono‐ubiquitination (H2AK119ub). B cell‐specific Moloney murine leukemia virus Integration site 1 (BMI1) and really interesting new gene 1B (RING1B) are PRC1 core components and...

Full description

Bibliographic Details
Main Authors: Kwang‐Su Park, Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong, Arum Kim, Gang Greg Wang, Husnu Ümit Kaniskan, Jian Jin
Format: Article
Language:English
Published: Wiley 2023-04-01
Series:Advanced Science
Subjects:
BMI1
degrader
embryonic ectoderm development (EED)
polycomb repressive complex 1 (PRC1)
proteolysis targeting chimera (PROTAC)
 RING1B
Online Access:https://doi.org/10.1002/advs.202205573

Internet

https://doi.org/10.1002/advs.202205573

Similar Items