Rare c-KIT c.1926delA and c.1936T>G Mutations in Exon 13 Define Imatinib Resistance in Gastrointestinal Stromal Tumors and Melanoma Patients: Case Reports and Cell Experiments

Rare c-KIT c.1926delA and c.1936T>G Mutations in Exon 13 Define Imatinib Resistance in Gastrointestinal Stromal Tumors and Melanoma Patients: Case Reports and Cell Experiments

Background: Target therapies play more and more important roles in gastrointestinal stromal tumors (GISTs) and melanoma with the advancement of clinical drugs that overcome the resistance caused by gene mutations. c-KIT gene mutations account for a large portion of GIST patients, which are known to...

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Bibliographic Details
Main Authors: Chi Yan, Chengzhi Zhao, Ke Yang, Hongyan Zhou, Limin Jing, Weixing Zhao, Wenguang Dou, Qingxin Xia, Jie Ma, Bing Wei, Yongjun Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
GIST
c-KIT
melanoma
rare mutations
imatinib resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.730213/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.730213/full

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