Stress Keratin 17 Is a Predictive Biomarker Inversely Associated with Response to Immune Check-Point Blockade in Head and Neck Squamous Cell Carcinomas and Beyond

Stress Keratin 17 Is a Predictive Biomarker Inversely Associated with Response to Immune Check-Point Blockade in Head and Neck Squamous Cell Carcinomas and Beyond

Low response rates in immune check-point blockade (ICB)-treated head and neck squamous cell carcinoma (HNSCC) drive a critical need for robust, clinically validated predictive biomarkers. Our group previously showed that stress keratin 17 (CK17) suppresses macrophage-mediated CXCL9/CXCL10 chemokine...

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Bibliographic Details
Main Authors: Taja Lozar, Israa Laklouk, Athena E. Golfinos, Niki Gavrielatou, Jin Xu, Christopher Flynn, Aysenur Keske, Menggang Yu, Justine Y. Bruce, Wei Wang, Cvetka Grasic Kuhar, Howard H. Bailey, Paul M. Harari, Huy Q. Dinh, David L. Rimm, Rong Hu, Paul F. Lambert, Megan B. Fitzpatrick
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cancers
Subjects:
stress keratin 17
cytokeratin 17
predictive biomarker
immune check-point inhibitors
pembrolizumab
head and neck cancer
Online Access:https://www.mdpi.com/2072-6694/15/19/4905

Internet

https://www.mdpi.com/2072-6694/15/19/4905

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