The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

Background: Intercellular communication mediated by cationic fluxes through the Connexin family of gap junctions regulates glucose-stimulated insulin secretion and beta cell defense against inflammatory stress. Rotigaptide (RG, ZP123) is a peptide analog that increases intercellular conductance in c...

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Bibliographic Details
Main Authors: Seyed Mojtaba Ghiasi, Jakob Bondo Hansen, Dan Ploug Christensen, Björn Tyrberg, Thomas Mandrup-Poulsen
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
beta cell
inflammation
insulin
NF-κB
gap junctions
Online Access:https://www.mdpi.com/1422-0067/21/12/4311

Internet

https://www.mdpi.com/1422-0067/21/12/4311

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