Analysis of AT7519 as a pro-resolution compound in an acetaminophen-induced mouse model of acute inflammation by UPLC-MS/MS

Abstract Background Uncontrolled inflammation contributes to the progression of organ damage in acute conditions, such as acetaminophen-induced acute liver injury (APAP-ALI) and there are limited treatments for this condition. AT7519, a cyclic-dependent kinase inhibitor (CDKI), has been used success...

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Bibliographic Details
Main Authors: Jennifer A. Cartwright, Joanna P. Simpson, Natalie Z. M. Homer, Adriano G. Rossi
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Inflammation
Subjects:
Online Access:https://doi.org/10.1186/s12950-023-00345-y