Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype

Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype

Centronuclear myopathy (CNM) is a congenital myopathy that is histopathologically characterized by centrally located nuclei, central aggregation of oxidative activity, and type I fiber predominance and hypotrophy. Here, we obtained commercially available mice overexpressing phospholamban (PlnOE), a...

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Bibliographic Details
Main Authors: Val A. Fajardo, Eric Bombardier, Elliott McMillan, Khanh Tran, Brennan J. Wadsworth, Daniel Gamu, Andrew Hopf, Chris Vigna, Ian C. Smith, Catherine Bellissimo, Robin N. Michel, Mark A. Tarnopolsky, Joe Quadrilatero, A. Russell Tupling
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Disease Models & Mechanisms
Subjects:
SERCA
Dynamin 2
Skeletal muscle
Calcium regulation
Congenital myopathy
Online Access:http://dmm.biologists.org/content/8/8/999

Internet

http://dmm.biologists.org/content/8/8/999

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