Synthesis and Radiolabelling of DOTA-Linked Glutamine Analogues with 67,68Ga as Markers for Increased Glutamine Metabolism in Tumour Cells

Synthesis and Radiolabelling of DOTA-Linked Glutamine Analogues with 67,68Ga as Markers for Increased Glutamine Metabolism in Tumour Cells

DOTA-linked glutamine analogues with a C6- alkyl and polyethyleneglycol (PEG) chain between the chelating group and the L-glutamine moiety were synthesised and labelled with 67,68Ga using established methods. High yields were achieved for the radiolabelling of the molecules with both radionuclides (...

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Bibliographic Details
Main Authors: Ivan Greguric, Andrew G. Katsifis, Elisabeth Oehlke, Nigel A. Lengkeek, Nicholas R. Howell, Rachael K. Shepherd, Paul A. Pellegrini
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Molecules
Subjects:
PET
67,68gallium
glutamine
amino acid transporter
radiochemistry
DOTA
Online Access:http://www.mdpi.com/1420-3049/18/6/7160

Internet

http://www.mdpi.com/1420-3049/18/6/7160

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