wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome.

wnt16 regulates spine and muscle morphogenesis through parallel signals from notochord and dermomyotome.

Bone and muscle are coupled through developmental, mechanical, paracrine, and autocrine signals. Genetic variants at the CPED1-WNT16 locus are dually associated with bone- and muscle-related traits. While Wnt16 is necessary for bone mass and strength, this fails to explain pleiotropy at this locus....

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Bibliographic Details
Main Authors: Claire J Watson, W Joyce Tang, Maria F Rojas, Imke A K Fiedler, Ernesto Morfin Montes de Oca, Andrea R Cronrath, Lulu K Callies, Avery Angell Swearer, Ali R Ahmed, Visali Sethuraman, Sumaya Addish, Gist H Farr, Arianna Ericka Gómez, Jyoti Rai, Adrian T Monstad-Rios, Edith M Gardiner, David Karasik, Lisa Maves, Bjorn Busse, Yi-Hsiang Hsu, Ronald Young Kwon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010496

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https://doi.org/10.1371/journal.pgen.1010496

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