Epigenetic Silencing of STAT3-Targeted miR-193a, by Constitutive Activation of JAK/STAT Signaling, Leads to Tumor Progression Through Overexpression of YWHAZ in Gastric Cancer

Epigenetic Silencing of STAT3-Targeted miR-193a, by Constitutive Activation of JAK/STAT Signaling, Leads to Tumor Progression Through Overexpression of YWHAZ in Gastric Cancer

PurposeThe purpose of this study was to identify genes that were epigenetically silenced by STAT3 in gastric cancer.MethodsMBDcap-Seq and expression microarray were performed to identify genes that were epigenetically silenced in AGS gastric cancer cell lines depleted of STAT3. Cell lines and animal...

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Main Authors: Kuo-Liang Wei, Jian-Liang Chou, Yin-Chen Chen, Jie-Ting Low, Guan-Ling Lin, Jing-Lan Liu, Te-Sheng Chang, Wei-Ming Chen, Yung-Yu Hsieh, Pearlly S. Yan, Yu-Ming Chuang, Jora M. J. Lin, Shu-Fen Wu, Ming-Ko Chiang, Chin Li, Cheng-Shyong Wu, Michael W. Y. Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
STAT3
epigenetics
miR-193a
YWHAZ
gastric cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.575667/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.575667/full

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