A Critical Role for p53 during the HPV16 Life Cycle

A Critical Role for p53 during the HPV16 Life Cycle

ABSTRACT Human papillomaviruses (HPV) are causative agents in ano-genital and oral cancers; HPV16 is the most prevalent type detected in human cancers. The HPV16 E6 protein targets p53 for proteasomal degradation to facilitate proliferation of the HPV16 infected cell. However, in HPV16 immortalized...

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Bibliographic Details
Main Authors: Christian T. Fontan, Claire D. James, Apurva T. Prabhakar, Molly L. Bristol, Raymonde Otoa, Xu Wang, Elmira Karimi, Pavithra Rajagopalan, Devraj Basu, Iain M. Morgan
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
human papillomavirus
E2
p53
cervical cancer
head and neck cancer
life cycle
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00681-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00681-22

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