Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization

Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization

Abstract Background Numerous studies have identified the proinflammatory, pronociceptive effects of morphine which ultimately exacerbate pain. Our novel endomorphin analog ZH853 does not produce proinflammatory effects on its own and gives potent, long-lasting analgesia. This study investigates whet...

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Bibliographic Details
Main Authors: Amy K. Feehan, James E. Zadina
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Neuroinflammation
Subjects:
Endomorphin
Latent sensitization
Chronic pain
Opioid
Morphine
Paw incision
Online Access:http://link.springer.com/article/10.1186/s12974-019-1480-x

Internet

http://link.springer.com/article/10.1186/s12974-019-1480-x

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