Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors

Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors

Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB ligand (RANKL). Rab11A GTPase, belonging to Rab11 subfamily representing the largest branch of Ras superfamily of small GTPa...

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Bibliographic Details
Main Authors: Yuka Okusha, Manh Tien Tran, Mami Itagaki, Chiharu Sogawa, Takanori Eguchi, Tatsuo Okui, Tomoko Kadowaki, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
Rab11A
c-fms
RANK
NFATc-1
osteoclast
vesicular transport
Online Access:https://www.mdpi.com/2073-4409/9/11/2384

Internet

https://www.mdpi.com/2073-4409/9/11/2384

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