Combined Pharmacophore and Grid-Independent Molecular Descriptors (GRIND) Analysis to Probe 3D Features of Inositol 1,4,5-Trisphosphate Receptor (IP<sub>3</sub>R) Inhibitors in Cancer

Combined Pharmacophore and Grid-Independent Molecular Descriptors (GRIND) Analysis to Probe 3D Features of Inositol 1,4,5-Trisphosphate Receptor (IP<sub>3</sub>R) Inhibitors in Cancer

Inositol 1, 4, 5-trisphosphate receptor (IP<sub>3</sub>R)-mediated Ca<sup>2+</sup> signaling plays a pivotal role in different cellular processes, including cell proliferation and cell death. Remodeling Ca<sup>2+</sup> signals by targeting the downstream effectors...

Full description

Bibliographic Details
Main Authors: Humaira Ismatullah, Ishrat Jabeen
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
IP<sub>3</sub>R-mediated Ca<sup>2+</sup> signaling
IP<sub>3</sub>R modulators
pharmacophore modeling
virtual screening
hits
GRIND model
Online Access:https://www.mdpi.com/1422-0067/22/23/12993

Internet

https://www.mdpi.com/1422-0067/22/23/12993

Similar Items