Combined Pharmacophore and Grid-Independent Molecular Descriptors (GRIND) Analysis to Probe 3D Features of Inositol 1,4,5-Trisphosphate Receptor (IP<sub>3</sub>R) Inhibitors in Cancer

Combined Pharmacophore and Grid-Independent Molecular Descriptors (GRIND) Analysis to Probe 3D Features of Inositol 1,4,5-Trisphosphate Receptor (IP<sub>3</sub>R) Inhibitors in Cancer

Inositol 1, 4, 5-trisphosphate receptor (IP<sub>3</sub>R)-mediated Ca<sup>2+</sup> signaling plays a pivotal role in different cellular processes, including cell proliferation and cell death. Remodeling Ca<sup>2+</sup> signals by targeting the downstream effectors...

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Bibliographic Details
Main Authors:	Humaira Ismatullah, Ishrat Jabeen
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	International Journal of Molecular Sciences
Subjects:	IP<sub>3</sub>R-mediated Ca<sup>2+</sup> signaling IP<sub>3</sub>R modulators pharmacophore modeling virtual screening hits GRIND model
Online Access:	https://www.mdpi.com/1422-0067/22/23/12993

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