Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides

Serum albumin binding knob domains engineered within a VH framework III bispecific antibody format and as chimeric peptides

BackgroundSerum albumin binding is an established mechanism to extend the serum half-life of antibody fragments and peptides. The cysteine rich knob domains, isolated from bovine antibody ultralong CDRH3, are the smallest single chain antibody fragments described to date and versatile tools for prot...

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Bibliographic Details
Main Authors: Ralph Adams, Callum Joyce, Mikhail Kuravskiy, Katriona Harrison, Zainab Ahdash, Matthew Balmforth, Kelda Chia, Cinzia Marceddu, Matthew Coates, James Snowden, Emmanuel Goursaud, Karelle Ménochet, Jean van den Elsen, Richard J. Payne, Alastair D. G. Lawson, Anthony Scott-Tucker, Alex Macpherson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
knob domain
bispecific
albumin
ultralong CDRH3
peptide
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170357/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170357/full

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