Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability

Importance of glutamine in synaptic vesicles revealed by functional studies of SLC6A17 and its mutations pathogenic for intellectual disability

Human mutations in the gene encoding the solute carrier (SLC) 6A17 caused intellectual disability (ID). The physiological role of SLC6A17 and pathogenesis of SLC6A17-based-ID were both unclear. Here, we report learning deficits in Slc6a17 knockout and point mutant mice. Biochemistry, proteomic, and...

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Bibliographic Details
Main Authors: Xiaobo Jia, Jiemin Zhu, Xiling Bian, Sulin Liu, Sihan Yu, Wenjun Liang, Lifen Jiang, Renbo Mao, Wenxia Zhang, Yi Rao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-07-01
Series:eLife
Subjects:
SLC6A17
learning
memory
glutamine
synaptic vesicle
Online Access:https://elifesciences.org/articles/86972

Internet

https://elifesciences.org/articles/86972

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