TRPM2 Is Not Required for T-Cell Activation and Differentiation

TRPM2 Is Not Required for T-Cell Activation and Differentiation

Antigen recognition by the T-cell receptor induces a cytosolic Ca2+ signal that is crucial for T-cell function. The Ca2+ channel TRPM2 (transient receptor potential cation channel subfamily M member 2) has been shown to facilitate influx of extracellular Ca2+ through the plasma membrane of T cells....

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Bibliographic Details
Main Authors: Niels C. Lory, Mikolaj Nawrocki, Martina Corazza, Joanna Schmid, Valéa Schumacher, Tanja Bedke, Stephan Menzel, Friedrich Koch-Nolte, Andreas H. Guse, Samuel Huber, Hans-Willi Mittrücker
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
TRPM2
T cells
T-cell activation
TCR signaling
ADPR
calcium signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.778916/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.778916/full

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