Effects of esketamine on postoperative rebound pain in patients undergoing unilateral total knee arthroplasty: a single-center, randomized, double-blind, placebo-controlled trial protocol

Effects of esketamine on postoperative rebound pain in patients undergoing unilateral total knee arthroplasty: a single-center, randomized, double-blind, placebo-controlled trial protocol

IntroductionRebound pain, transient and acute postoperative pain after the disappearance of regional block anesthesia, has been a concern in recent years. Insufficient preemptive analgesia and hyperalgesia induced by regional block are the main mechanisms. At present, the evidence for the treatment...

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Bibliographic Details
Main Authors: Youzhuang Zhu, Qun Li, Guilin Liu, Fang Sheng, Xiaotian Zhang, Lili Jiang, Shaona Li, Jianshuai He, Zhijin Zou, Baobo Zhang, Changyao Wang, Xin Jiang, Yang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Neurology
Subjects:
total knee arthroplasty
esketamine
rebound pain
postoperative acute pain
hyperalgesia
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1179673/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2023.1179673/full

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