Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro

Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro

Alzheimer’s disease (AD) is characterized by intracellular tau aggregates and extracellular deposition of amyloid-β (Aβ). The major genetic risk factor to develop AD is the Apolipoprotein E isoform 4 (ApoE4). ApoE4 may directly affect Aβ pathology, yet the exact role of ApoE4 in the progression of A...

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Bibliographic Details
Main Authors: Christiane Muth, Alexander Hartmann, Diego Sepulveda-Falla, Markus Glatzel, Susanne Krasemann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
apolipoprotein E
microglia
cytoskeleton
cell motility
phagocytosis
cell signaling
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00181/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00181/full

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