Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease

Complementary multi-omics approach, in silico metabolic flux, and neuroimaging analyses link the sphingolipid pathway to Alzheimer’s disease pathogenesis with therapeutic targets validated using behavioral assessments in amyloidogenic APP/PS1 mice.

Bibliographic Details
Main Authors: Priyanka Baloni, Matthias Arnold, Luna Buitrago, Kwangsik Nho, Herman Moreno, Kevin Huynh, Barbara Brauner, Gregory Louie, Alexandra Kueider-Paisley, Karsten Suhre, Andrew J. Saykin, Kim Ekroos, Peter J. Meikle, Leroy Hood, Nathan D. Price, The Alzheimer’s Disease Metabolomics Consortium, P. Murali Doraiswamy, Cory C. Funk, A. Iván Hernández, Gabi Kastenmüller, Rebecca Baillie, Xianlin Han, Rima Kaddurah-Daouk
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04011-6

Internet

https://doi.org/10.1038/s42003-022-04011-6

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