Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis

Organelle contact sites are multifunctional platforms for maintaining cellular homeostasis. Alternations of the mitochondria-associated membranes (MAM), one of the organelle contact sites where the endoplasmic reticulum (ER) is tethered to the mitochondria, have been involved in the pathogenesis of...

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Bibliographic Details
Main Authors: Seiji Watanabe, Mai Horiuchi, Yuri Murata, Okiru Komine, Noe Kawade, Akira Sobue, Koji Yamanaka
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Neurobiology of Disease
Subjects:
mitochondoria-associated membrane
sigma-1 receptor
AAA ATPase domain-containing protein  3A
amyotrophic lateral sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123000451

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http://www.sciencedirect.com/science/article/pii/S0969996123000451

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