Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects

Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects

Abstract Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu2R and mGlu3R) in brains of schizophrenia patients may explain the limited efficacy of mGlu2/3R ligands in clinical trials. Studies evaluating mGlu2/3R levels in well-designed, large postmorte...

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Bibliographic Details
Main Authors: Jon DelaCuesta-Barrutia, Oihane Martínez-Peula, Guadalupe Rivero, Jon A. Santas-Martín, Eva Munarriz-Cuezva, Iria Brocos-Mosquera, Patricia Miranda-Azpiazu, Rebeca Diez-Alarcia, Benito Morentin, William G. Honer, Luis F. Callado, Amaia M. Erdozain, Alfredo Ramos-Miguel
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-02832-z

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https://doi.org/10.1038/s41398-024-02832-z

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