Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.

Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression.

DNA mismatch repair suppresses gastrointestinal tumorgenesis. Four mammalian E. coli MutL homologues heterodimerize to form three distinct complexes: MLH1/PMS2, MLH1/MLH3, and MLH1/PMS1. To understand the mechanistic contributions of MLH3 and PMS2 in gastrointestinal tumor suppression, we generated...

Descripció completa

Dades bibliogràfiques
Autors principals:	Peng-Chieh Chen, Mari Kuraguchi, John Velasquez, Yuxun Wang, Kan Yang, Robert Edwards, Dan Gillen, Winfried Edelmann, Raju Kucherlapati, Steven M Lipkin
Format:	Article
Idioma:	English
Publicat:	Public Library of Science (PLoS) 2008-06-01
Col·lecció:	PLoS Genetics
Accés en línia:	http://europepmc.org/articles/PMC2410297?pdf=render

Ítems similars

Genotype directed therapy in murine mismatch repair deficient tumors.
per: Melanie H Kucherlapati, et al.
Publicat: (2013-01-01)

Genetic mechanisms in Apc-mediated mammary tumorigenesis.
per: Mari Kuraguchi, et al.
Publicat: (2009-02-01)

Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques
per: Simon Deycmar, et al.
Publicat: (2024-03-01)

Vaccines for immunoprevention of DNA mismatch repair deficient cancers
per: Steven Lipkin, et al.
Publicat: (2022-06-01)

Downregulation of SPTAN1 is related to MLH1 deficiency and metastasis in colorectal cancer.
per: Anne Ackermann, et al.
Publicat: (2019-01-01)

MLH1 Deficiency Down-Regulates TLR4 Expression in Sporadic Colorectal Cancer
per: Melania Scarpa, et al.
Publicat: (2021-05-01)

Mismatch repair genes Mlh1 and Mlh3 modify CAG instability in Huntington's disease mice: genome-wide and candidate approaches.
per: Ricardo Mouro Pinto, et al.
Publicat: (2013-10-01)

The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans.
per: Carol M Manhart, et al.
Publicat: (2017-04-01)

Roles of BCCIP deficiency in mammary tumorigenesis
per: Roberto Droz-Rosario, et al.
Publicat: (2017-10-01)

Constitutional mismatch repair-deficiency syndrome
per: Katharina Wimmer, et al.
Publicat: (2010-05-01)

Mismatch Repair Deficiency and Microsatellite Instability
per: Sandra Schöniger, et al.
Publicat: (2022-08-01)

Cited1 deficiency suppresses intestinal tumorigenesis.
per: Valérie Méniel, et al.
Publicat: (2013-01-01)

Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth.
per: Berna Somuncu, et al.
Publicat: (2022-01-01)

Targeting mitochondrial DNA polymerase gamma for selective inhibition of MLH1 deficient colon cancer growth
per: Berna Somuncu, et al.
Publicat: (2022-01-01)

Biallelic Mismatch Repair Deficiency in an Adolescent Female
per: Amber Hildreth, et al.
Publicat: (2018-01-01)

Mismatch repair deficiency in bilateral breast cancer
per: Milena Massumi Kozonoe, et al.
Publicat: (2024-08-01)

Unexplained mismatch repair deficiency: Case closed
per: Ellis L. Eikenboom, et al.
Publicat: (2023-01-01)

Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein
per: Mev Dominguez‐Valentin, et al.
Publicat: (2014-07-01)

Constitutional mismatch repair deficiency syndrome with atypical features caused by a homozygous MLH1 missense variant (c.1918C>A, p.(Pro640Thr)): a case report
per: Firas Akrout, et al.
Publicat: (2023-08-01)

Low frequency of mismatch repair deficiency in gallbladder cancer
per: Benjamin Goeppert, et al.
Publicat: (2019-05-01)

Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer
per: Yurong Song, et al.
Publicat: (2023-09-01)

DNA mismatch repair MLH1 gene polymorphism and infertility in azoospermia males in Iraqi Kurdish population
per: Muhsin Jamil Abdulwahid, et al.
Publicat: (2023-12-01)

Mismatch repair protein and MLH1 methylation status as predictors of response to adjuvant therapy in endometrial cancer
per: Mikko Loukovaara, et al.
Publicat: (2021-02-01)

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function
per: Gloria X. Reyes, et al.
Publicat: (2020-12-01)

Tle6 deficiency in male mice led to abnormal sperm morphology and reduced sperm motility
per: Kousuke Kazama, et al.
Publicat: (2024-10-01)

Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation
per: Guiping Yu, et al.
Publicat: (2022-11-01)

Practical guidance for mismatch repair-deficiency testing in endometrial cancer
per: Stelloo, E, et al.
Publicat: (2016)

Cerebral developmental venous anomalies in children with mismatch repair deficiency
per: Buket Kara, et al.
Publicat: (2022-12-01)

The efficiency of neoadjuvant chemotherapy in colon cancer with mismatch repair deficiency
per: Wu Yunlong, et al.
Publicat: (2023-02-01)

Mismatch repair protein deficiency in triple-negative breast carcinomas
per: Bayan Maraqa, et al.
Publicat: (2024-06-01)

Immune escape and resistance to immunotherapy in mismatch repair deficient tumors
per: Guillaume Mestrallet, et al.
Publicat: (2023-07-01)

DNA mismatch repair deficient (dMMR) endometrial cancer
per: Chia-Hao Liu, et al.
Publicat: (2022-09-01)

The THE FREQUENCY OF MISMATCH REPAIR DEFICIENCY IN COLORECTAL CARCINOMA DETERMINED BY IMMUNOHISTOCHEMISTRY
per: Maria Naseem, et al.
Publicat: (2021-08-01)

Combination pembrolizumab and lenvatinib in metastatic mismatch repair deficient adenocarcinoma of Mullerian origin: A case report
per: Jessica M. Velasquez, et al.
Publicat: (2024-06-01)

MLH1 Deficiency Induces Cetuximab Resistance in Colon Cancer via Her‐2/PI3K/AKT Signaling
per: Ying Han, et al.
Publicat: (2020-07-01)

Teenage-Onset Colorectal Cancers in a Digenic Cancer Predisposition Syndrome Provide Clues for the Interaction between Mismatch Repair and Polymerase δ Proofreading Deficiency in Tumorigenesis
per: Esther Schamschula, et al.
Publicat: (2022-09-01)

Constitutional mismatch repair deficiency mimicking Lynch syndrome is associated with hypomorphic mismatch repair gene variants
per: Richard Gallon, et al.
Publicat: (2024-05-01)

Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development
per: Yutong WANG, et al.
Publicat: (2020-12-01)

First reported case of alveolar soft part sarcoma in constitutional mismatch repair deficiency syndrome tumor spectrum - diagnosed in one of the siblings with constitutional mismatch repair deficiency
per: Mitul Bipinchandra Modi, et al.
Publicat: (2017-01-01)

The role of Atg5 gene in tumorigenesis under autophagy deficiency conditions
per: Hsiao‐Sheng Liu, et al.
Publicat: (2024-07-01)