Recombinant production of the lantibiotic nisin using Corynebacterium glutamicum in a two-step process

Recombinant production of the lantibiotic nisin using Corynebacterium glutamicum in a two-step process

Abstract Background The bacteriocin nisin is naturally produced by Lactococcus lactis as an inactive prepeptide that is modified posttranslationally resulting in five (methyl-)lanthionine rings characteristic for class Ia bacteriocins. Export and proteolytic cleavage of the leader peptide results in...

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Bibliographic Details
Main Authors: Dominik Weixler, Max Berghoff, Kirill V. Ovchinnikov, Sebastian Reich, Oliver Goldbeck, Gerd M. Seibold, Christoph Wittmann, Nadav S. Bar, Bernhard J. Eikmanns, Dzung B. Diep, Christian U. Riedel
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Microbial Cell Factories
Subjects:
Corynebacterium glutamicum
Bacteriocin
Nisin
Recombinant production
Pre-nisin
Biosensor
Online Access:https://doi.org/10.1186/s12934-022-01739-y

Internet

https://doi.org/10.1186/s12934-022-01739-y

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