Change in the Single Amino Acid Site 83 in Rabies Virus Glycoprotein Enhances the BBB Permeability and Reduces Viral Pathogenicity

Change in the Single Amino Acid Site 83 in Rabies Virus Glycoprotein Enhances the BBB Permeability and Reduces Viral Pathogenicity

Lab-attenuated rabies virus (RABV) is a highly cellular adaptation and less pathogenic than wild-type RABV. However, the molecular mechanisms that regulate the cellular adaptation and pathogenicity remain obscure. In this work, we isolated a wild-type RABV (CNIM1701) from a rabid bovine in northern...

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Bibliographic Details
Main Authors: Chunfu Li, Yongzhi Wang, Huiting Liu, Xinghua Zhang, Dalai Baolige, Shihua Zhao, Wei Hu, Yang Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
rabies virus
glycoprotein
pathogenicity
blood-brain barrier
MMPs
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.632957/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.632957/full

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