Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells

Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells

Abstract Background Hypoacetylation on histone H3 of human prostate cancer cells has been described. Little is known about the modifications of other histones from prostate cancer cells. Methods Histones were isolated from the prostate cancer cell line DU-145 and the non-malignant prostatic cell lin...

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Bibliographic Details
Main Authors: Shundong Cang, Xiaobin Xu, Yuehua Ma, Delong Liu, J. W. Chiao
Format: Article
Language:English
Published: BMC 2016-01-01
Series:Journal of Hematology & Oncology
Subjects:
Epigenomes
Histone H2B modifications
Mass spectrometry
Acetylation
Deacetylases
Hypoacetylation
Online Access:http://link.springer.com/article/10.1186/s13045-016-0233-x

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http://link.springer.com/article/10.1186/s13045-016-0233-x

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