Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.

Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R.

Adenosine is a widespread neuromodulator within the CNS and its extracellular level is increased during hypoxia or intense synaptic activity, modulating pre- and postsynaptic sites. We studied the neuromodulatory action of adenosine on glutamatergic currents in the hippocampus, showing that activati...

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Bibliographic Details
Main Authors: Silvia eDi Angelantonio, Cristina eBertollini, Sonia ePiccinin, Maria eRosito, Flavia eTrettel, Francesca ePagani, Cristina eLimatola, Davide eRagozzino
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
AMPA receptors
adenosine receptors
hippocampal neurons
A3R
neuronal modulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00409/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00409/full

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