Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in <i>Tetrahymena</i>

Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in <i>Tetrahymena</i>

Locus-specific gene amplification and genome-wide endoreplication generate the elevated copy number of ribosomal DNA (rDNA, 9000 C) and non-rDNA (90 C) chromosomes in the developing macronucleus of <i>Tetrahymena thermophila</i>. Subsequently, all macronuclear chromosomes replicate once...

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Bibliographic Details
Main Authors: Xiangzhou Meng, Hung Quang Dang, Geoffrey M. Kapler
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Microorganisms
Subjects:
DNA replication
endoreplication
gene amplification
macronuclear development
<i>Tetrahymena thermophila</i>
Online Access:https://www.mdpi.com/2076-2607/11/2/491

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https://www.mdpi.com/2076-2607/11/2/491

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