11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy

11β-HSD1 plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy

Abstract Background Despite their efficacy in the treatment of chronic inflammation, the prolonged application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects including glucocorticoid-induced osteoporosis (GIOP). 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1)...

Full description

Bibliographic Details
Main Authors: C. G. Fenton, C. L. Doig, S. Fareed, A. Naylor, A. P. Morrell, O. Addison, C. Wehmeyer, C. D. Buckley, M. S. Cooper, G. G. Lavery, K. Raza, R. S. Hardy
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Arthritis Research & Therapy
Subjects:
Glucocorticoids
Osteoporosis
11β-HSD1
Trabecular bone
Online Access:http://link.springer.com/article/10.1186/s13075-019-1972-1

Internet

http://link.springer.com/article/10.1186/s13075-019-1972-1

Similar Items