Oxygen level is a critical regulator of human B cell differentiation and IgG class switch recombination

Oxygen level is a critical regulator of human B cell differentiation and IgG class switch recombination

The generation of high-affinity antibodies requires an efficient germinal center (GC) response. As differentiating B cells cycle between GC dark and light zones they encounter different oxygen pressures (pO2). However, it is essentially unknown if and how variations in pO2 affect B cell differentiat...

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Bibliographic Details
Main Authors: Jana Koers, Casper Marsman, Juulke Steuten, Simon Tol, Ninotska I. L. Derksen, Anja ten Brinke, S. Marieke van Ham, Theo Rispens
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
B cells
hypoxia
germinal center
differentiation
antibody-secreting cell
class switch recombination
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082154/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082154/full

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