Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis
The adequate performance and correct interpretation of assays for coagulation factor inhibitors play a critical role for the hemostasis laboratory. Both, false positive and false negative inhibitor assays may be reported, leading to erroneous patient’s management. Therefore, we decided to present a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-07-01
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| Series: | Romanian Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/rrlm-2017-0026 |
| _version_ | 1829498431058477056 |
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| author | Arghirescu Smaranda Boia Eugen Ursu Emilia Savescu Delia Boc Madalina Jinca Cristian Serban Margit |
| author_facet | Arghirescu Smaranda Boia Eugen Ursu Emilia Savescu Delia Boc Madalina Jinca Cristian Serban Margit |
| author_sort | Arghirescu Smaranda |
| collection | DOAJ |
| description | The adequate performance and correct interpretation of assays for coagulation factor inhibitors play a critical role for the hemostasis laboratory. Both, false positive and false negative inhibitor assays may be reported, leading to erroneous patient’s management. Therefore, we decided to present a case with a spurious image of an exceptionally rare acquired combined haemophilia A, B and C, with severe factor ( F) VIII, IX and XI deficiency, associated with high titre anti - F VIII, IX and XI inhibitors in a 4 years old girl with Henoch-Schönlein type vasculitis. Finally, performing, beside coagulometric methods also antigenic ELISA assays, we had to invalidate the diagnosis. The performance of antiphospholipd antibodies clarified the diagnosis , finally concluding as definite diagnosis Transient Lupus Anticoagulant Syndrome, with decisive impact on therapy and follow-up. |
| first_indexed | 2024-12-16T08:13:02Z |
| format | Article |
| id | doaj.art-5c4ae30472074f4a8cfa2532ebabde9e |
| institution | Directory Open Access Journal |
| issn | 2284-5623 |
| language | English |
| last_indexed | 2024-12-16T08:13:02Z |
| publishDate | 2017-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Laboratory Medicine |
| spelling | doaj.art-5c4ae30472074f4a8cfa2532ebabde9e2022-12-21T22:38:19ZengSciendoRomanian Journal of Laboratory Medicine2284-56232017-07-0125329530010.1515/rrlm-2017-0026rrlm-2017-0026Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitisArghirescu Smaranda0Boia Eugen1Ursu Emilia2Savescu Delia3Boc Madalina4Jinca Cristian5Serban Margit6University of Medicine and Pharmacy “Victor Babes”Timisoara, Timisoara, RomaniaUniversity of Medicine and Pharmacy “Victor Babes”Timisoara, Timisoara, RomaniaClinical Emergency Children’s Hospital “Louis Turcanu”Timisoara, Timisoara, RomaniaClinical Emergency Children’s Hospital “Louis Turcanu”Timisoara, Timisoara, RomaniaClinical Emergency Children’s Hospital “Louis Turcanu”Timisoara, Timisoara, RomaniaUniversity of Medicine and Pharmacy “Victor Babes”Timisoara, Timisoara, RomaniaClinical Emergency Children’s Hospital “Louis Turcanu”Timisoara, Timisoara, RomaniaThe adequate performance and correct interpretation of assays for coagulation factor inhibitors play a critical role for the hemostasis laboratory. Both, false positive and false negative inhibitor assays may be reported, leading to erroneous patient’s management. Therefore, we decided to present a case with a spurious image of an exceptionally rare acquired combined haemophilia A, B and C, with severe factor ( F) VIII, IX and XI deficiency, associated with high titre anti - F VIII, IX and XI inhibitors in a 4 years old girl with Henoch-Schönlein type vasculitis. Finally, performing, beside coagulometric methods also antigenic ELISA assays, we had to invalidate the diagnosis. The performance of antiphospholipd antibodies clarified the diagnosis , finally concluding as definite diagnosis Transient Lupus Anticoagulant Syndrome, with decisive impact on therapy and follow-up.https://doi.org/10.1515/rrlm-2017-0026acquired haemophilialupus anticoagulanthenoch-schönlein vasculitischildrenantiphospholipid antibody syndrome |
| spellingShingle | Arghirescu Smaranda Boia Eugen Ursu Emilia Savescu Delia Boc Madalina Jinca Cristian Serban Margit Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis Romanian Journal of Laboratory Medicine acquired haemophilia lupus anticoagulant henoch-schönlein vasculitis children antiphospholipid antibody syndrome |
| title | Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis |
| title_full | Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis |
| title_fullStr | Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis |
| title_full_unstemmed | Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis |
| title_short | Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis |
| title_sort | pitfalls in hemostasis exploration a case report of a girl with henoch schonlein type vasculitis |
| topic | acquired haemophilia lupus anticoagulant henoch-schönlein vasculitis children antiphospholipid antibody syndrome |
| url | https://doi.org/10.1515/rrlm-2017-0026 |
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