SARS-CoV-2 Vaccination Responses in Anti-CD20-Treated Progressive Multiple Sclerosis Patients Show Immunosenescence in Antigen-Specific B and T Cells

SARS-CoV-2 Vaccination Responses in Anti-CD20-Treated Progressive Multiple Sclerosis Patients Show Immunosenescence in Antigen-Specific B and T Cells

Clinical, pathological, and imaging evidence in multiple sclerosis (MS) shows that inflammation starts early and progresses with age. B cells play a central role in this process, contributing to cytokine production, defective regulatory functions, and abnormal immunoglobulin production, even in the...

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Bibliographic Details
Main Authors: Sara De Biasi, Alin Liviu Ciobanu, Elena Santacroce, Domenico Lo Tartaro, Gianluca Degliesposti, Miriam D’Angerio, Maristella Leccese, Martina Cardi, Tommaso Trenti, Michela Cuccorese, Lara Gibellini, Diana Ferraro, Andrea Cossarizza
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Vaccines
Subjects:
multiple sclerosis
immune response
vaccines
phenotyping
biomarkers
flow cytometry
Online Access:https://www.mdpi.com/2076-393X/12/8/924

Internet

https://www.mdpi.com/2076-393X/12/8/924

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