Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study

Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study

BackgroundXanthine oxidase is involved in the production of uric acid and the generation of superoxide anion. We evaluated the long-term effect of febuxostat, a non-purine selective xanthine oxidase inhibitor, on endothelial function in patients with asymptomatic hyperuricemia.MethodsIn the PRIZE st...

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Bibliographic Details
Main Authors: Tatsuya Maruhashi, Yukihito Higashi, Hisako Yoshida, Atsushi Tanaka, Kazuo Eguchi, Hirofumi Tomiyama, Kazuomi Kario, Toru Kato, Nozomu Oda, Nobuhiro Tahara, Mitsutoshi Oguri, Hirotaka Watada, Koichi Node
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
xanthine oxidase
xanthine oxidase inhibitor
febuxostat
flow-mediated vasodilation
endothelial function
hyperuricemia
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.882821/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.882821/full

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