Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study
BackgroundXanthine oxidase is involved in the production of uric acid and the generation of superoxide anion. We evaluated the long-term effect of febuxostat, a non-purine selective xanthine oxidase inhibitor, on endothelial function in patients with asymptomatic hyperuricemia.MethodsIn the PRIZE st...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.882821/full |
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| author | Tatsuya Maruhashi Yukihito Higashi Yukihito Higashi Hisako Yoshida Atsushi Tanaka Kazuo Eguchi Hirofumi Tomiyama Kazuomi Kario Toru Kato Nozomu Oda Nobuhiro Tahara Mitsutoshi Oguri Hirotaka Watada Koichi Node |
| author_facet | Tatsuya Maruhashi Yukihito Higashi Yukihito Higashi Hisako Yoshida Atsushi Tanaka Kazuo Eguchi Hirofumi Tomiyama Kazuomi Kario Toru Kato Nozomu Oda Nobuhiro Tahara Mitsutoshi Oguri Hirotaka Watada Koichi Node |
| author_sort | Tatsuya Maruhashi |
| collection | DOAJ |
| description | BackgroundXanthine oxidase is involved in the production of uric acid and the generation of superoxide anion. We evaluated the long-term effect of febuxostat, a non-purine selective xanthine oxidase inhibitor, on endothelial function in patients with asymptomatic hyperuricemia.MethodsIn the PRIZE study, patients with hyperuricemia were randomly assigned to either add-on febuxostat treatment (febuxostat group) or non-pharmacologic hyperuricemia treatment (control group). Among the 514 participants, endothelial function was assessed in 41 patients in the febuxostat group and 38 patients in the control group by flow-mediated vasodilation (FMD) of the brachial artery at the beginning of the study and after 12 and/or 24 months of treatment (63 men; median age, 68.0 years).ResultsThe least squares mean concentration of serum uric acid was significantly lower in the febuxostat group than in the control group at 6 months (mean between-group difference [febuxostat group - control group], −2.09 mg/dL [95% confidence interval (CI), −2.520 to −1.659]; P < 0.001), 12 months (mean between-group difference, −2.28 mg/dL [95% CI, −2.709 to −1.842]; P < 0.001), and 24 months (mean between-group difference, −2.61 mg/dL [95% CI, −3.059 to −2.169]; P < 0.001). No significant differences were found between groups in the least squares mean estimated percentage change in FMD at 12 months (mean between-group difference, −0.56% [95% CI, −1.670 to 0.548]; P = 0.319) and at 24 months (mean between-group difference, −0.60% [95% CI, −1.886 to 0.685]; P = 0.357).ConclusionFebuxostat treatment did not alter endothelial function assessed by FMD during a 2-year study period in patients with asymptomatic hyperuricemia. |
| first_indexed | 2024-12-12T15:41:29Z |
| format | Article |
| id | doaj.art-5c4cd3f06f6c47798ecee9c3619ead53 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-12T15:41:29Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5c4cd3f06f6c47798ecee9c3619ead532022-12-22T00:19:54ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.882821882821Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE StudyTatsuya Maruhashi0Yukihito Higashi1Yukihito Higashi2Hisako Yoshida3Atsushi Tanaka4Kazuo Eguchi5Hirofumi Tomiyama6Kazuomi Kario7Toru Kato8Nozomu Oda9Nobuhiro Tahara10Mitsutoshi Oguri11Hirotaka Watada12Koichi Node13Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, JapanDepartment of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, JapanDivision of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, JapanDepartment of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Cardiovascular Medicine, Saga University, Saga, JapanDepartment of General Internal Medicine, Saitama Red Cross Hospital, Saitama, JapanDepartment of Cardiology, Tokyo Medical University, Tokyo, JapanDepartment of Medicine, Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Shimotsuke, JapanDepartment of Clinical Research, National Hospital Organization, Tochigi Medical Center, Utsunomiya, JapanDepartment of Cardiology, Hiroshima Prefectural Hospital, Hiroshima, Japan0Division of Cardiovascular Medicine, Department of Medicine, Kurume University School of Medicine, Kurume, Japan1Department of Cardiology, Kasugai Municipal Hospital, Kasugai, Japan2Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, JapanDepartment of Cardiovascular Medicine, Saga University, Saga, JapanBackgroundXanthine oxidase is involved in the production of uric acid and the generation of superoxide anion. We evaluated the long-term effect of febuxostat, a non-purine selective xanthine oxidase inhibitor, on endothelial function in patients with asymptomatic hyperuricemia.MethodsIn the PRIZE study, patients with hyperuricemia were randomly assigned to either add-on febuxostat treatment (febuxostat group) or non-pharmacologic hyperuricemia treatment (control group). Among the 514 participants, endothelial function was assessed in 41 patients in the febuxostat group and 38 patients in the control group by flow-mediated vasodilation (FMD) of the brachial artery at the beginning of the study and after 12 and/or 24 months of treatment (63 men; median age, 68.0 years).ResultsThe least squares mean concentration of serum uric acid was significantly lower in the febuxostat group than in the control group at 6 months (mean between-group difference [febuxostat group - control group], −2.09 mg/dL [95% confidence interval (CI), −2.520 to −1.659]; P < 0.001), 12 months (mean between-group difference, −2.28 mg/dL [95% CI, −2.709 to −1.842]; P < 0.001), and 24 months (mean between-group difference, −2.61 mg/dL [95% CI, −3.059 to −2.169]; P < 0.001). No significant differences were found between groups in the least squares mean estimated percentage change in FMD at 12 months (mean between-group difference, −0.56% [95% CI, −1.670 to 0.548]; P = 0.319) and at 24 months (mean between-group difference, −0.60% [95% CI, −1.886 to 0.685]; P = 0.357).ConclusionFebuxostat treatment did not alter endothelial function assessed by FMD during a 2-year study period in patients with asymptomatic hyperuricemia.https://www.frontiersin.org/articles/10.3389/fcvm.2022.882821/fullxanthine oxidasexanthine oxidase inhibitorfebuxostatflow-mediated vasodilationendothelial functionhyperuricemia |
| spellingShingle | Tatsuya Maruhashi Yukihito Higashi Yukihito Higashi Hisako Yoshida Atsushi Tanaka Kazuo Eguchi Hirofumi Tomiyama Kazuomi Kario Toru Kato Nozomu Oda Nobuhiro Tahara Mitsutoshi Oguri Hirotaka Watada Koichi Node Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study Frontiers in Cardiovascular Medicine xanthine oxidase xanthine oxidase inhibitor febuxostat flow-mediated vasodilation endothelial function hyperuricemia |
| title | Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study |
| title_full | Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study |
| title_fullStr | Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study |
| title_full_unstemmed | Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study |
| title_short | Long-Term Effect of Febuxostat on Endothelial Function in Patients With Asymptomatic Hyperuricemia: A Sub-Analysis of the PRIZE Study |
| title_sort | long term effect of febuxostat on endothelial function in patients with asymptomatic hyperuricemia a sub analysis of the prize study |
| topic | xanthine oxidase xanthine oxidase inhibitor febuxostat flow-mediated vasodilation endothelial function hyperuricemia |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.882821/full |
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