Integrative analysis of CRISPR screening data uncovers new opportunities for optimizing cancer immunotherapy

Integrative analysis of CRISPR screening data uncovers new opportunities for optimizing cancer immunotherapy

Abstract Background In recent years, the application of functional genetic immuno-oncology screens has showcased the striking ability to identify potential regulators engaged in tumor-immune interactions. Although these screens have yielded substantial data, few studies have attempted to systematica...

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Bibliographic Details
Main Authors: Yan Li, Chen Yang, Zhicheng Liu, Shangce Du, Susan Can, Hailin Zhang, Linmeng Zhang, Xiaowen Huang, Zhenyu Xiao, Xiaobo Li, Jingyuan Fang, Wenxin Qin, Chong Sun, Cun Wang, Jun Chen, Huimin Chen
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Molecular Cancer
Subjects:
CRISPR screen
Tumor immunity
MON2
Immune checkpoint blockade
Drug repurposing
Connectivity map
Online Access:https://doi.org/10.1186/s12943-021-01462-z

Internet

https://doi.org/10.1186/s12943-021-01462-z

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