Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord

Oxaliplatin is a chemotherapeutic agent that is effective against various types of cancer including colorectal cancer. Acute cold hyperalgesia is a serious side effect of oxaliplatin treatment. Although the therapeutic drug pregabalin is beneficial for preventing peripheral neuropathic pain by targe...

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Bibliographic Details
Main Authors: Ken Yamamoto, Mayuko Tsuboi, Toshie Kambe, Kenji Abe, Yoshihiko Nakatani, Kazuyoshi Kawakami, Iku Utsunomiya, Kyoji Taguchi
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316000074