Oral Selective TLR8 Agonist Selgantolimod Induces Multiple Immune Cell Responses in Humans

Oral Selective TLR8 Agonist Selgantolimod Induces Multiple Immune Cell Responses in Humans

TLR8 agonists have the potential for use as immunomodulatory components in therapeutic modalities for viral infections such as chronic HBV (CHB) and HIV. In this study, using peripheral blood samples from a phase 1a clinical trial, we examined the acute effects of a single oral administration of a s...

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Bibliographic Details
Main Authors: Natarajan Ayithan, Alip Ghosh, Ankit Dwivedi, Jeffrey J. Wallin, Susanna K. Tan, Diana Chen, Shyam Kottilil, Bhawna Poonia
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Viruses
Subjects:
toll-like receptor 8 (TLR8)
chronic hepatitis B
mucosal-associated invariant T (MAIT)
activation marker
pro-inflammatory cytokine
microarray
Online Access:https://www.mdpi.com/1999-4915/13/12/2400

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https://www.mdpi.com/1999-4915/13/12/2400

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