Physiological Effects of Hydrolyzed Skim Milk and Probiotics on Osteoporosis Models
Osteoporosis, a skeletal metabolic disease characterized by low bone mineral density and deterioration of bone microarchitecture, frequently occurs in postmenopausal women older than 50 years. Milk and dairy products are essential calcium sources recommended for bone health. In this study, we analyz...
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MDPI AG
2023-09-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/13/18/10424 |
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| author | Heyon-Woo Shim Won-Yong Lee Hyoun Wook Kim Jin-ki Park Kwanghyun Cho Joon Mo Yeo Hyun-Jung Park |
| author_facet | Heyon-Woo Shim Won-Yong Lee Hyoun Wook Kim Jin-ki Park Kwanghyun Cho Joon Mo Yeo Hyun-Jung Park |
| author_sort | Heyon-Woo Shim |
| collection | DOAJ |
| description | Osteoporosis, a skeletal metabolic disease characterized by low bone mineral density and deterioration of bone microarchitecture, frequently occurs in postmenopausal women older than 50 years. Milk and dairy products are essential calcium sources recommended for bone health. In this study, we analyzed the effects of skim milk and probiotics in an ovariectomized osteoporosis model. Body weight significantly increased, whereas the consumption of skim milk and probiotics significantly decreased (approximately 20%) in the ovariectomized models. In addition, the concentration of calcium was significantly 0.5 mg/dL higher in the skim-milk-with-probiotic group than in the ovariectomized group. The bone volume/tissue volume ratio, trabecular thickness, trabecular number, and trabecular separation were higher in the skim-milk and skim-milk-with-probiotic groups than in the ovariectomized group. Histological analysis of the small intestine revealed that the consumption of skim milk alone or in combination with probiotics increased the lengths of the villus, crypt, and serosa. These results verify the beneficial effects of milk products in osteoporosis models, which may enable higher milk and milk product consumption by older women. |
| first_indexed | 2024-03-10T23:04:21Z |
| format | Article |
| id | doaj.art-5c58323716564626bdce9ba21c2b93db |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T23:04:21Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-5c58323716564626bdce9ba21c2b93db2023-11-19T09:27:34ZengMDPI AGApplied Sciences2076-34172023-09-0113181042410.3390/app131810424Physiological Effects of Hydrolyzed Skim Milk and Probiotics on Osteoporosis ModelsHeyon-Woo Shim0Won-Yong Lee1Hyoun Wook Kim2Jin-ki Park3Kwanghyun Cho4Joon Mo Yeo5Hyun-Jung Park6Department of Animal Biotechnology, College of Life Science, Sangji University, Wonju 26339, Republic of KoreaDepartment of Livestock, Korea National University of Agriculture and Fisheries, Jeonju 54874, Republic of KoreaAnimal Products Research and Development Division, National Institute of Animal Science, Rural Development Administration, Wanju 55365, Republic of KoreaDepartment of Livestock, Korea National University of Agriculture and Fisheries, Jeonju 54874, Republic of KoreaDepartment of Livestock, Korea National University of Agriculture and Fisheries, Jeonju 54874, Republic of KoreaDepartment of Livestock, Korea National University of Agriculture and Fisheries, Jeonju 54874, Republic of KoreaDepartment of Animal Biotechnology, College of Life Science, Sangji University, Wonju 26339, Republic of KoreaOsteoporosis, a skeletal metabolic disease characterized by low bone mineral density and deterioration of bone microarchitecture, frequently occurs in postmenopausal women older than 50 years. Milk and dairy products are essential calcium sources recommended for bone health. In this study, we analyzed the effects of skim milk and probiotics in an ovariectomized osteoporosis model. Body weight significantly increased, whereas the consumption of skim milk and probiotics significantly decreased (approximately 20%) in the ovariectomized models. In addition, the concentration of calcium was significantly 0.5 mg/dL higher in the skim-milk-with-probiotic group than in the ovariectomized group. The bone volume/tissue volume ratio, trabecular thickness, trabecular number, and trabecular separation were higher in the skim-milk and skim-milk-with-probiotic groups than in the ovariectomized group. Histological analysis of the small intestine revealed that the consumption of skim milk alone or in combination with probiotics increased the lengths of the villus, crypt, and serosa. These results verify the beneficial effects of milk products in osteoporosis models, which may enable higher milk and milk product consumption by older women.https://www.mdpi.com/2076-3417/13/18/10424skim milkprobioticsosteoporosisovariectomized model |
| spellingShingle | Heyon-Woo Shim Won-Yong Lee Hyoun Wook Kim Jin-ki Park Kwanghyun Cho Joon Mo Yeo Hyun-Jung Park Physiological Effects of Hydrolyzed Skim Milk and Probiotics on Osteoporosis Models Applied Sciences skim milk probiotics osteoporosis ovariectomized model |
| title | Physiological Effects of Hydrolyzed Skim Milk and Probiotics on Osteoporosis Models |
| title_full | Physiological Effects of Hydrolyzed Skim Milk and Probiotics on Osteoporosis Models |
| title_fullStr | Physiological Effects of Hydrolyzed Skim Milk and Probiotics on Osteoporosis Models |
| title_full_unstemmed | Physiological Effects of Hydrolyzed Skim Milk and Probiotics on Osteoporosis Models |
| title_short | Physiological Effects of Hydrolyzed Skim Milk and Probiotics on Osteoporosis Models |
| title_sort | physiological effects of hydrolyzed skim milk and probiotics on osteoporosis models |
| topic | skim milk probiotics osteoporosis ovariectomized model |
| url | https://www.mdpi.com/2076-3417/13/18/10424 |
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